Sanjay's Quick takes

By Sanjay @ 2023-03-23T11:54 (+7)

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Sanjay @ 2023-12-14T09:38 (+25)

I'm used to seeing many expert opinions on psychotherapy converge on the view that the type of therapy doesn't make much difference (at least as far as the evidence can tell us). I.e. it doesn't seem to matter much whether you choose CBT or IPT or whatever. The therapeutic alliance, on the other hand, does matter. Therapeutic alliance means something like "How well you get on with your therapist" (plus some related things).

I had a fleeting thought that perhaps the therapeutic alliance might be neglected. E.g. maybe there's a novel intervention which involves training therapists really heavily on how to improve the therapeutic alliance, and skimping on (or entirely ignoring?) traditional therapeutic methods.

I suspect that this fleeting thought is probably not correct.

Firstly, a quick look at google scholar found loads of meta-analyses. One of them started with "The alliance continues to be one of the most investigated variables related to success in psychotherapy".

Secondly, the intervention that I imagined (training therapists to focus on the alliance) arguably already exists. Rogerian therapy (also known as person-centred therapy) is one of the main forms of therapy, and it arguably focuses heavily on the alliance (I'm glossing over a bunch of nuances about Rogerian therapy).

Thirdly, the effect size seems to be small, as far as I can tell (having not looked into this carefully). Arnow & Steidman 2014 stated that "Overall, meta-analytic findings reveal that the magnitude of the alliance-outcome relationship is modest, accounting for 5-8% of the variance in outcome."

So it actually seems that the alliance is getting loads of attention relative to its importance, I suspect. If I looked into this more carefully, it's possible I could change my mind again, but I suspect I won't look into it more carefully.

geoffrey @ 2023-12-15T05:08 (+5)

I always read therapeutic alliance as advice for the patient, where one should try many therapists before finding one that fits. I imagine therapists are already putting a lot of effort on the alliance front

Perhaps an intervention could be an information campaign to tell patients more about this? I feel it’s not well known or to obvious that you can (1) tell your therapist their approach isn’t working and (2) switch around a ton before potentially finding a fit

I haven’t looked much into it though

Sanjay @ 2023-12-15T14:23 (+2)

My intuition says that people are probably already following the heuristic "if you don't like your therapist, try to get another one". I also haven't given much thought to the patient's/client's perspective on the therapeutic alliance.

Linch @ 2023-12-19T07:27 (+4)

How likely is this to be a real effect vs a confound? I imagine if I feel like therapy is working, I'm much more likely to like my therapist (similarly I'm more likely to like a physical trainer if I'm getting healthier, I'm more likely to like my teacher if I feel like I'm learning more, etc)

Sanjay @ 2023-12-19T20:12 (+2)

Good question. 

It's also helpful because the wording of my post was meant to convey that "expert opinions tend to believe that the therapeutic alliance matters" (and not necessarily that I'm confident that that's the case). 

One of the papers that I referenced did flag that most of the studies are observational rather than experimental, which does validate your concern. (I think it was Arnow & Steidman 2014 which said this; I don't know if a more recent paper sheds more light on this).

I'm not planning to look into this topic in any depth, but perhaps someone more knowledgeable can give a more definitive answer.

Sanjay @ 2026-01-17T23:41 (+21)

According to someone I chatted to at a party (not normally the optimal way to identify top new cause areas!) fungi might be a worrying new source of pandemics because of climate change.

Apparently this is because thermal barriers prevented fungi from infecting humans, but because fungi are adapting to higher temperatures, they are now better able to overcome those barriers. This article has a bit more on this:

https://theecologist.org/2026/jan/06/age-fungi

Purportedly, this is even more scary than a pathogen you can catch from people, because you can catch this from the soil.

I suspect that if this were, in fact, the case, I would have heard about it sooner. Interested to hear comments from people who know more about it than me, or have more capacity than me to read up about it a bit.

Jenny Kudmowa @ 2026-01-19T19:31 (+12)

Hi Sanjay,

When people ask me "What is one area or issue you wish people paid more attention to in global health?", I almost always say fungal diseases.

I co-authored some reports on fungal infections (e.g., this one), and my impression is that it is indeed very plausible and well-recognized by experts that fungal infections will rise in a major way as a result of climate change, though I have not seen any guesses / estimates of how large the additional burden could be.

I think the more important point is that, regardless of climate change, fungal diseases are a massive disease burden source already. Fungal disease-related deaths are plausibly on the order of ~2M/year, likely more, and it is possible that DALYs are in a similar ballpark as TB, malaria, and HIV (though again unclear, because fungal diseases aren't even comprehensively included in IHME's global burden of disease estimates yet).

It is also incredibly neglected, to an extent that I find almost unbelievable. Though this has recently improved a bit, with more attention / funding from the Wellcome Trust coming in.

I think one reason that people aren't jumping on fungal diseases despite high importance and neglectedness is that tractability is tricky. Fungal disease treatments are often not very effective, expensive, difficult to administer, and have lots of side effects. Also, there are LOTS of different fungal diseases, that all affect different populations, manifest differently, and require different diagnostics/treatment. So there isn't really an easy one-size-fits-all solution here.

I do not find it surprising that you haven't heard about it. Lots of people I know haven't, and there are several reasons for this that are too long to explain here (though this article might help).

Maybe helpful for you to know that Coefficient Giving have done internal research on fungal diseases (they also commissioned our work on this topic), so they might have more thoughts on this.

SiobhanBall @ 2026-01-19T21:15 (+4)

Hi Jenny, very interesting, thank you. What was the response of CG to your report, and do you know if they are planning to invest more resources towards this potential cause area? 

Jenny Kudmowa @ 2026-01-20T09:22 (+3)

I'm not able to comment on CG's reaction to the report, as those discussions are confidential.

What I can say is that they are still exploring this area internally (given that they commissioned us to do more work related to fungal diseases recently (see here)).

I’m not aware of any specific grantmaking decisions or commitments at this stage.

NickLaing @ 2026-01-18T22:26 (+4)

Thanks this is super interesting and definitely concerning.

FWIW within the non-EA Global Health Community this has been a topic of conversation for the last 3-4 years. It is potential threat, but still seems like a super low percentage Xish-risk, because...

a) We haven't actually seen anything terribly dangerous happen yet
b) Antifungal medications are there, and if there was a super-dangerous-mass fungal threat I suspect we could make better ones pretty quicksmart. But yes this is far from guaranteed.

As a side note there are already plenty of pathogens we catch from the soil like anthrax and tetanus, as well as worms like hookworm!

Sanjay @ 2026-01-18T23:40 (+4)

The person I spoke to at the party said that he knew somebody who had a fungal infection and was likely to die from it.

I don't know much about antifungals, but I infer from his comment that we don't have enough antifungals to cover all of the potential fungal infections.

Jenny Kudmowa @ 2026-01-19T19:47 (+3)

To my knowledge, there are a few (not actually that many) existing antifungals, but as I commented above, they mostly aren't very good, and in several deadly fungal infections they are almost pointless.

Also, when a new fungal pathogen comes out, it might be harmless, or it might be big trouble, nobody can predict that. A good example I've seen mentioned a few times is Candida Auris (pretty serious and often deadly fungal infection) that emerged in 2009 independently in several regions of the world, pretty much out of nowhere. And the scary thing is that it was drug-resistant from the start! I think researchers aren't quite sure why it emerged, but it could be related to climate change.

feijão @ 2026-01-18T22:01 (+1)

The idea of fungi evolving to infect humans and resulting in apocalypse underpins the premise of the famous game and TV series "The Last of Us"

Given the series' critical acclaim and popularity, I wonder if it also demonstrates potential for engaging the public with this topic through mainstream popular media.

SiobhanBall @ 2026-01-19T20:58 (+1)

I was wondering if anyone was going to mention that. There was a lot of media buzz about whether the events of the show could really happen at the time of its airing. This piece by Yale is supposed to sound reassuring, but it just... doesn't. :/ 

K.F. Martin @ 2026-01-19T20:50 (+1)

Among other things, the natural-atrocity take on zombies is what got me in love with the TV series; depressed by them but interested in this new aesthetic of dangerous nature globally killing human civilization, think overgrown moss on broken subways. I can indeed see things like it motivating EA people to prevent such things, very much involved with visions of such a world. 🪸

Sanjay @ 2023-03-23T11:54 (+13)

Someone pinged me a message on here asking about how to donate to tackle child sexual abuse. I'm copying my thoughts here.

I haven't done a careful review on this, but here's a few quick comments:

If anyone is interested in this topic and wants to put aside a substantial sum (high 5 digits or six digits) then the next steps would involve a number of conversations to gather more evidence and check whether existing interventions are as lacking in evidence as I suspect. If so, the next step would be work on creating a new charity. It's possible that Charity Entrepreneurship might be interested in this, but I haven't spoken with them about this and I don't know their appetite. I'd be happy to support you on this, mostly because I know that CSA can be utterly horrific (at least some of the time). 

saulius @ 2023-03-24T00:20 (+8)

You may know this already, but No Means No Worldwide works with children and adolescents. E.g., the mean age of girls in this study is 12.3 years. Founders Pledge evaluated them (see here for a summary and here for a full report) and provisionally recommended them. I don't know if the person is particularly looking into tackling sexual abuse of younger children, but this charity seems worth mentioning as an option.

Sanjay @ 2023-03-24T11:03 (+6)

Thanks very much Saulius. 

In SoGive's 2023 plans document, we said 

"An investigation of No Means No Worldwide was suggested to us by a member of the EA London community, who was excited to have an EA-aligned recommendation for a charity which prevents sexual violence. We have mostly completed a review of this charity, and were asked not to publish it yet because it used a study which is not yet in the public domain."

That said, part of the reason I didn't allude to NMNW is that my vague memory of the average was older (presumably my vague memory was wrong).

Sanjay @ 2023-04-12T22:01 (+7)

Will everyone code 2-3x more quickly because of AI?

To get a sense of the impact of AI on coding, I conducted a survey of around 100 coders and people working in IT.

Respondents estimated, on average, that code could be developed in around 50% as much time (i.e. twice as quickly) in light of the fact that AI tools like GPT-4 exist. This was just assuming that AI stays as good as it is now. If they incorporated the fact that AI might get better, the estimate moved to almost 3x as good.

Of respondents who said that they were coders, 56% said they had already started using Large Language Models (LLMs) like GPT-4.

There are several reasons to think the 2-3x forecast might not be correct:

I don't know about the extent to which current forecasts of AI timelines are accounting for this effect.

You can scrutinise my work here: https://docs.google.com/spreadsheets/d/1I3_0kiwCJKzpuRlc66ytQVSDAXLd8wj2NmYhpZ28m94/edit#gid=990899939

kpurens @ 2023-04-13T16:31 (+2)

This is a really good piece of input for predictions of how the supply-demand curve for coding will change in the future. 

50% increase in time effectively reduces cost of coding by 50%. Depending on the shape of the supply-demand curve for coding, this could lead to high unemployment, or a boom for coders that leads to even higher demand. 

Note:  coding productivity tools developed over the past 40 years have led to ever-increasing demand since so much value is generated :)